IMMUNOHISTOCHEMICAL EXPRESSION OF P53 PROTEIN AND PCNA IN GASTRIC MUCINOUS ADENOCARCINOMAS

The aim of this study is to review the histopathological features and to examine the immunohistochemical expression of tumor supressor gene; p53 protein and proliferating cell nuclear antigen (PCNA) in gastric mucinous adenocarsinomas. Among 24 cases, 46% have high proliferative activity by PCNA labeling index. When PCNA labeling index and p53 expression have been correlated with clinicopathologic characteristics, no significant association has been found statistically, except a significant association between age and PCNA activity.