MOLECULAR ANALYSIS OF T(14;18) TRANSLOCATION IN NON-HODGKIN'S LYMPHOMA

The chromosomal translocation t(14;18) in non-Hodgkin's lymphoma patiens can be determined by using bcl-2 and immunoglobulin heavy chain specific probes. In this study 44 patients were analyzed for t(14;18) translocation and in 9 patients bcl-2 and in 18 patients immunoglobulin chain rearrengements wede found. We concluded that molecular analysis of peripheral blood samples of malignant lymphoma patients is an effective method for determining translocations.