METHODS
One hundred and thirty-eight patients (63 females, 75 males) diagnosed with high grade glial tumors were analysed retrospectively to evaluate radiotherapy results and the prognostic factors. Radiotherapy was given after complete resection on 51 patients and after partial resection on 47 patients. The remaining 40 patients were irradiated after biopsy. Fifty-five patients received concomittant and/or adjuvant chemotherapy.
RESULTS
Median overall survival and progression free survival were 13 and 6 months. One and 2-year survival rates were %55 and %24 respectively. Univariate analysis showed that age (p=0.0021, p=0.0021), histology (p=0.0079, p=0.00001), resection type (p=0.04, p=0.01), Karnofsky Performance Status (KPS) (p=0.00001, p=0.00001) and Recursive Partitioning Analysis (RPA) (p=0.00001, p=0.000001) classification were the significant prognostic factors for the progression-free and overall survival. In multivariate analysis, KPS (p=0.03322), and RPA (p=0.0033) classification were the independent significant prognostic factors for overall and progression free survival respectively.
CONCLUSION
In our series KPS and RPA classification were the most significant prognostic factors for the progression and survival.
Keywords: High grade glial tumors; prognostic factors; radiotherapy; survival
