METHODS
The rats (n=48) were divided randomly and equally into six
groups as: Control (C), NAC (received 1000 mg/kg NAC),
WR-2721 (200 mg/kg WR-2721), Radiation (R, received irradiation),
R + NAC (received irradiation and 1000 mg/kg
NAC), and R + WR-2721 (received irradiation and 200 mg/kg
WR-2721). All the irradiated groups received whole-body
gamma irradiation as a single dose of 6 Gy. At 72th hours, the
rats were sacrificed and bone marrow cells were bilaterally collected
from rats' femur. Then, cytogenetic and cytotoxicity
tests were performed according to convantional methods.
RESULTS
Group R showed significantly higher CA and lower MI values
when compared to C. R + NAC and R + WR-2721 groups
showed significantly lower CA and higher MI averages when
compared to R.
CONCLUSION
The results give clues about the beneficial effects of NAC
against radiation-induced genocytotoxicity.
Keywords: N-acetylcysteine; irradiation-injury; WR-2721
