Turkish Journal of Oncology Turkish Society for Radiation Oncology
Article Open Access Volume 24 · Issue 4 · 2009 pp. 172–176

Chronic lymphocytic thyroiditis and tumor-infiltrating lymphocytes combined in thyroid papillary carcinoma

Nilüfer ONAK KANDEMİR1
1 Zonguldak Karaelmas Üniversitesi Tıp Fakültesi, Patoloji Anabilim Dalı, Zonguldak
2 Dr. Lütfi Kırdar Kartal Eğitim ve Araştırma Hastanesi, Patoloji Kliniği, İstanbul
Published: 2009 Pubmed: 88441 Article ID: 736
Abstract
OBJECTIVES

This study examined the frequency of chronic lymphocytic
thyroiditis (CLT) in thyroid papillary carcinomas (TPC) and
the relationship between the presence of tumor-infiltrating
lymphocytes (TIL) and CLT.


METHODS

The study included 61 TPC cases. In each case, the presence
of the lymphocyte infiltration in the tumor tissue and nonneoplastic
parenchyma was graded semi-quantitatively using a
scale of 0 to 3. The cases were classified in two groups, TPC including
CLT (Group I) and TPC not including CLT (Group II).


RESULTS

CLT was detected in 26.3% (Group I) of the TPCs and TIL
was observed in 77% of the Group I cases; no lymphoid infiltration
compatible with TIL was detected in Group II. A significant
difference was observed in the TIL density between
Groups I and II.


CONCLUSION

CLT is a frequent finding in TPC, and the presence of TIL is
related to CLT.

Keywords: Lymphocytic thyroiditis; papillary carcinoma; thyroid; tumor-infiltrating lymphocytes

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