To our knowledge, no acute myeloblastic leukemia (AML) development
has been observed in bilateral breast cancer (BC) patients.
A 57-year-old woman was admitted for epistaxis attacks.
She was diagnosed as therapy-related myelodysplastic syndrome
(MDS)-AML and later died due to multiple organ failure. She
had mastectomy and radiotherapy (RT) for invasive ductal cancer
(IDC) when referred to the hospital with a lump in her right breast
24 years ago. Evaluation for a lump in her left breast 4 years ago
also resulted in IDC diagnosis. Mastectomy, RT and chemotherapy
including anthracycline (A) and cyclophosphamide (C) were
performed. During the follow-up, cough developed and examination
showed right pulmonary infiltration and paratracheal lymphadenomegaly.
Biopsy showed IDC infiltration. She underwent
chemotherapy with AC. Drugs and RT, which are known to have
leukemogenic effect in BC, should be used carefully because
treatment-related leukemias are resistant to treatment.
Keywords: Acute myeloblastic leukemia; breast cancer
