5-Fluorouracil-associated bradycardia: case report

5-Fluorouracil (5-FU) is a synthetic, fluorinated pyrimidine
antagonist, which is a cytostatic agent. Cardiotoxicity is a rare
but important side effect of 5-FU. The cardiotoxicity incidence
of 5-FU is increasing in conjunction with its frequent use in
chemotherapy protocols. Ischemic symptoms and signs related
to 5-FU are observed during the late phase of the drug
administration. Monitoring should be done in all patients having
coronary artery disease. There are many treatment options
and prophylactic modalities for 5-FU cardiotoxicity. Herein,
we present the rare case of a patient with cardiotoxicity during
short 5-FU infusion.

Keywords: Bradycardia; chemotherapy; 5-fluorouracil