Turkish Journal of Oncology Turkish Society for Radiation Oncology
Article Open Access Volume 25 · 2010 pp. 135–142

Evaluation of prognostic factors on survival in patients with lymph node negative gastric cancer: three centers experience

Ahmet BİLİCİ1
1 Dr. Lütfi Kırdar Kartal Eğitim ve Araştırma Hastanesi, Tıbbi Onkoloji Kliniği, İstanbul
2 Marmara Üniversitesi Tıp Fakültesi, Tıbbi Onkoloji Bilim Dalı, İstanbul
3 Dr. Lütfi Kırdar Kartal Eğitim ve Araştırma Hastanesi, Genel Cerrahi Kliniği, İstanbul
4 Kocaeli Üniversitesi, Tıp Fakültesi, Tıbbi Onkoloji Bilim Dalı, Kocaeli
Published: 2010 Pubmed: 95781 Article ID: 760
Abstract
OBJECTIVES

In our study, prognostic factors associated with overall survival
(OS) and disease-free survival (DFS) in patients without lymph
node metastasis after curative surgery, were investigated.


METHODS

A total of 113 gastric cancer patients with lymph node negative
who had undergone curative gastrectomy, between 2003
and 2010, were retrospectively analyzed.


RESULTS

In the univariate analysis pT stage (p<0.001), clinical stage
(p<0.001), blood vessel invasion (p=0.033) and recurrence
(p<0.001) were found to be an important prognostic factors
for OS, while pT stage (p=0.004), clinical stage (p=0.001),
blood vessel invasion (p=0.016) and lymphatic vessel invasion
(p=0.031) were important prognostic indicators for DFS. Multivariate
analysis indicated that pT stage, clinical stage, histological
grade and recurrence were independent prognostic
factors for OS. Moreover, when multivariate analysis was performed
for DFS, surgery type, tumor size, pT stage and clinical
stage were found to be independent prognostic indicators.


CONCLUSION

Patients with lymph node negative gastric cancer have a high
curability and survival compared with cases with lymph node
metastasis.

Keywords: Overall survival; disease-free survival; lymph node negative tumors; gastric cancer

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