Ionizing radiation cell injury occurs by means of oxidative/
nitrosative stress mediators. Protection of normal tissues from
damage might increase the therapeutic ratio. It is shown that
acetylsalicylic acid (ASA), a member of the non-steroidal antiinflammatory
group, can inhibit the release of prostaglandins
that play a role in many forms of tissue damages and might
prevent tissue/cell damages in various diseases with its similar
anti-oxidant properties. With clinical/preclinical studies, it is
demonstrated that ASA can reduce oxidative damage/injury
and that it has a place in protection from cancer. It might be
stated that it reduces radiation/irradiation-based geno-cytotoxicity.
ASA is an agent that has not yet been used as a radioprotector
in the clinic, and it is worth being supported with more
advanced studies. In this examination, it is intended to discuss
the current role of ASA as a radioprotector.
Keywords: Acetylsalicylic acid; aspirin; irradiation injury
