Neuroblastoma is the most common extracranial solid tumour
in childhood. Neuroblastoma is sometimes seen with neurofibromatosis.
A one year old boy was investigated for fever,
anemia, subcutaneous soft tissue nodules, exophtalmus, horizontal
nystagmus, café-au lait spots, hepatosplenomegaly and
lymphadenomegaly and was referred to Pediatric Hematology-
Oncology clinic. The patient was initially diagnosed as
neurofibromatosis and juvenile myelomonocytic leukemia
but his final diagnosis was neuroblastoma. Neurofibroma and
neuroblastoma both originate from neural crest cells and they
share a common pathogenesis. It is important to evaluate children
who are diagnosed as neurofibromatosis for neuroblastoma
especially when there is a fast growing mass. Radiology
and urine catecholamine levels may be helpful in diagnosis.
Keywords: Child; juvenile myelomonocytic leukemia; neuroblastoma; neurofibromatosis
