METHODS
Acute toxicities of 101 prostate carcinoma patients, treated
with radical radiotherapy were evaluated. Prostate, prostate and
seminal vesicles, and pelvic lymph nodes were enrolled into the
treatment volume in 50, 40 and 11cases respectively. All patients
were planned with Eclipse treatment planning system using dynamic
IMRT/ VMAT. The median doses to the planning target
volumes of prostate, seminal vesicles and pelvic lymphatics
were 76Gy, 56Gy and 54Gy respectively, delivered simultaneously.
All patients were observed per week during radiotherapy
and at 1st and 3rd month following completion of therapy. Acute
toxicities were graded according to the RTOG scoring criteria.
RESULTS
Grade 2 and 1genitourinary acute toxicity were observed in 3
and 57 patients, respectively. Grade1 gastrointestinal toxicity
was detected in 15 patients, 3 patients developed grade1 skin
reaction. Grade 1 leukopenia was detected in 2 cases. No grade
3-4 toxicity was observed.
CONCLUSION
In prostate cancer, higher doses radiotherapy with kV-CBCT
guided IMRT/VMAT technique was given more accurately
and well tolerated. Expected side effects depending on size of
irradiated volume with pelvic radiotherapy, were not observed.
Keywords: Acute toxicity; prostate carcinoma; intensity modulated radiotherapy
