Guillain-Barre syndrome (GBS) is an acute inflammatory
demyelinating polyradiculoneuropathy characterized by bilateral
progressive symmetrical paralysis. GBS is rarely seen
neuropathy in cancer patients. In the literature some cases of
GBS associated with anticancer chemotherapy. In this case;
the guillain-barre syndrome developed after the treatment of a
59-year-old male patient with metastatic small cell lung carcinoma
who admitted to hospital with neutropenic fever after
cisplatin/etoposide chemoteraphy regime is presented. The patients
complained of bilteral progressive symmetrical paralysis
in upper and lower limbs with depressed deep tendon reflexes
and hypoesthesia. There was no pathological findings on electromyography.
There was no a sign at radiological imaging that
explained cranial and spinal mestastasis. The cerebrospinal
fluid had albuminocytologic dissociation. Decline in tumoral
lesions were detected on chest radiography. Accompanied by
clinical and laboratory findings, a diagnosis of Guillain-Barre
syndrome was considered. Semptoms completely disapperared
after intravenous immunoglobulin for five days. Recurrence did
not during follow-up. The patients was administered a total of
4 cycles of cisplatin / etoposide chemotherapy. The patient died
due to disease progression six months later. We think that, in
this case GBS was not a paraneoplatic syndrome because there
was more than 50% tumor shrinkage. We propose GBS was
induced by infection and chemotherapy rather than malignancy.
Keywords: Guillain-Barre sydrome; small cell lung cancer; neuropathy
