Limited stage small cell lung cancer: Treatment results and prognostic factors

METHODS

Fifty-two patients with limited stage small cell lung cancer
treated between 2005 and 2012, in our hospital were retrospectively
evaluated.

RESULTS

The 2-year overall survival and disease free survival rates were
48% and 15%. On univariate analysis T1 tumor (p=.012), concomittant
chemoradiotherapy (p=.023), start of radiotherapy
within the 3 months after diagnosis (p=.026) and prophylactic
cranial irradiation (p=.025) significantly improved disease
free survival rate. Concomittant chemoradiotherapy (p<.001),
early radiotherapy (p<.001) and prophylactic cranial irradiaton
(p=.001) significantly affected overall survival rate. On
multivariate analysis, only prophylactic cranial irradiation was
found to be an independent factor affecting overall survival
rate (p=.003).

CONCLUSION

Our results were consistent with the literature even though
small sample size. Prophylactic cranial irradiation was determined
the only independent factor that affects overall survival.

Keywords: Prophylactic cranial radiotherapy; limited stage small cell lung cancer; thoracic radiotherapy