Turkish Journal of Oncology Turkish Society for Radiation Oncology
Article Open Access Volume 40 · Issue 2 · 2025 pp. 163–163

Testicular Cancer Presenting with a Mass in The Duodenum Years Later

Songül CEBECI1, Rıza Umar GÜRSU2, Merve CIN3, Mert Mahsuni SEVINÇ4
1 Department of Internal Medicine, İstanbul Training and Research Hospital, İstanbul-Türkiye
2 Department of Oncology, İstanbul Training and Research Hospital, İstanbul-Türkiye
3 Department of Pathology, İstanbul Training and Research Hospital, İstanbul-Türkiye
4 Department of General Surgery, İstanbul Training and Research Hospital, İstanbul-Türkiye
Published: 2025 DOI: 10.5505/tjo.2025.4483 Article ID: 1507
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Introduction

Dear Editor,
Testicular cancer is the most common malignancy in young men, with germ cell tumors as the predominant subtype.[,] Typically metastatic sites include intraabdominal lymph nodes, lungs, and liver, metastases to the gastrointestinal system, particularly the duodenum, are exceedingly rare. This however is a rare occasion.[] Here, we report a unique case of a 40-year-old man who developed a duodenal metastasis from mixed germ cell testicular cancer ten years after initial diagnosis.

In 2014, the patient had mixed germ cell tumours and had a right radical orchiectomy and was treated with cisplatin-based chemotherapy for lungs which developed secondary metastasis. After treatment, he went into remission and remained disease free for the next ten years. In 2024, he presented with abdominal pain, and imaging revealed an obstructive duodenal mass, histopathologically confirmed as metastatic germ cell cancer. Despite surgical intervention and chemotherapy, the patient succumbed to pneumonia.

This case highlights the rare but possible late gastrointestinal metastasis of testicular cancer.[] Clinicians should consider this in patients with a history of testicular cancer presenting with gastrointestinal symptoms, even years after remission.

Conflict of Interest: All authors declared no conflict of interest.

Financial Support: None declared.

Use of AI for Writing Assistance: No AI technologies utilized.

Authorship Contributions: Concept - S.C.; Design - S.C.; Supervision - R.U.G.; Funding - S.C.; Materials - M.C., M.M.S.; Data analysis and/or interpretation - S.C.; Literature search - S.C.; Writing - S.C.; Critical review - R.U.G.

Peer-review: Externally peer-reviewed.

References

Vecchia CL, Bosetti C, Lucchini F, Bertuccio P, Negri E, Boyle P, et al. Cancer mortality in Europe. 2000- 2004 and an overview of trends since 1975. Ann Oncol 2010;21(6):1323-60. Al Ani AH, AL Ani HA. Testicular seminoma metastasis to duodenum. Misdiagnosed as primary duodenal tumor. Int J Surg Case Rep 2016;25:149-52. Senadhi V, Dutta S. Testicular seminoma metastases to the gastrointestinal tract and the necessity of surgery. J Gastrointest Cancer 2007;43(3):499-501. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ. Cancer statistics, 2009. Cancer J Clin 2009;59(4):225-249.

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