DIABETES INSIPITUS AND METASTATIC NEUROHYPOPHYSEAL CANCERS (CASE REPORTS AND REVIEW)

Diabetes Insipitus is an uncommon but well recognized complication of metastatic breast and broncogenic carcinomas. DI resulting from injury to the hypotalamic - neurohypophyseal axis occurs most commonly as a result of head trauma, neoplasm and granulomatous disease. A variety of tumors may metastasize to the pituitary gland. Metastasis to the pituitary selectively and commonly involves posterior pituitary rather than adenohypophysis. These are most frequently derived from a primary carcinoma of the breast and lung. In this article, two breast cancers and one malignant mesothelioma associated with diabetes Insipitus attributable to posterior pituitary metastasis were presented with a brief review of their clinical features, biochemical and radiological findings are reported with the literature review.