METHODS
Patients with RCC between April 2008 and July 2011 were
analyzed, retrospectively.
RESULTS
There were 209 RCC patients. Rate of sarcomatoid differentiation
was 3.3% (n=7). Median age was 53 (min 45-max 69).
Patients were men. Histological subtype was clear cell carcinoma
in 3 patients (42.9%) and chromophobic in 1 patient
(14.3%). Five of the patients (71.4%) were stage 4, one of
them (14.3%) was stage 3, and 1 of them (14.3%) stage 2.
Interferon treatment was administered to 2 patients (28.6%)
and antracyline based chemotherapy to 2 patients (28.6%)
as systemic therapies. In median 1 month follow-up (min:1 -
max:78) 4 of 7 patients (57.5%) were dead.
CONCLUSION
In the early stages of RCC, main treatment modality is surgery.
Gemcitabine-adriamycin, are used for sarcomatoid differentiated
RCC patients despite low response rates.
Keywords: Renal cell carcinoma; poor prognosis; sarcomatoid differentiation
