Angiogenesis and anti-angiogenic treatments in colorectal cancer

Angiogenesis is extremely important in cancer progression.
The therapeutic approaches that target regression of tumors
through suppression of angiogenesis have been under investigation
for a long time. In addition to chemotherapy, monotherapy
as well as monoclonal antibodies and tyrosine kinase
inhibitors increase the survival of patients with colorectal
cancer. Considering this point of view, understanding the intrinsic
molecular mechanisms will afford great opportunity to
develop targeted therapies to combat colorectal cancer.

Keywords: Angiogenesis; anti-angiogenic treatment; resistance to anti-angiogenic treatment; colorectal cancer; tyrosine kinase inhibitors