The value of the expressions of E-cadherin, Calretinin and GLUT-1 in the differential diagnosis of malignant mesothelioma, reactive mesothelial proliferation and adenocarcinoma in serous effusions

METHODS

The study group consisted of the cell blocks from 60 patients,
with 20 in each of the three groups. Immunocytochemistry
staining method was applied to the sections prepared from the
cell blocks of the selected cases.

RESULTS

In this study, strong expression of E-cadherin antibody in adenocarcinoma,
strong expression of Calretinin antibody in mesothelioma
and reactive mesothelial proliferation, and strong
expression of GLUT-1 antibody in mesothelioma and adenocarcinoma
were established.

CONCLUSION

The results of the present study revealed that E-cadherin antibody
can be successfully used as a marker for the differentiation
of adenocarcinoma from mesothelioma and reactive
mesothelial proliferation, Calretinin antibody can be used for
the differentiation of mesothelioma and reactive mesothelial
proliferation from adenocarcinoma, and GLUT-1 antibody can
be used for the differentiation of adenocarcinoma and mesothelioma
from reactive mesothelial proliferation.

Keywords: Adenocarcinoma; E-cadherin; GLUT-1; Calretinin; mesothelioma; reactive mesothelial proliferation